
During the evacuation of Earth, Professor Sam Tucker-head researcher on the Titan Project-leaves his young son Cale in the care of his alien friend Tek as he flees Earth in the spaceship Titan. Determined to wipe out humanity, the Drej destroy Earth in a massive attack, forcing the surviving humans to evacuate and flee into space.

In the year 3028, a groundbreaking scientific project known as "The Titan Project" incurs the wrath of the Drej, a hostile race of aliens with bodies of pure energy, who fear that it will allow humans to challenge them.
